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Role of apolipoproteins (Apo A1 and Apo B), Interleukin-6 (IL6), Copper (Cu) and Zinc (Zn) in patients with diabetic cardiac complications

Satish Ameta
Department of Biochemistry, Ananta Institute of Medical Sciences, Udaipur, Rajasthan

Manish Kalal
Department of Biochemistry, Pacific Medical College and Hospital, Udaipur, Rajasthan

Deepti Bhatt
Department of Biochemistry, RR Dental College, Udaipur, Rajasthan

Himanshu Patel
Department of Biochemistry, Banas Medical College and Research Institute, Palampur, India

Neha Sharma
Department of Biochemistry, Atal Binari Vitpaye Medical College, Faridabad

Background: Diabetes mellitus can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure. Diabetes is also associated with alteration in the amount of several classes of lipoprotein, apolipoproteins and minerals.

Objectives: To find out the correlation of Apolipoproteins Apo A1 and Apo B, IL6, Cu and Zn trace elements in diabetic patient with cardiac complications.

Materials and Methods: This study was performed on 50 patients with diabetic cardiac complications and 50 diabetic patients. Blood sample was collected by vein puncture using an aseptic technique. Serum was separated from the sample and was analyzed for biochemical parameters.

Results: Mean serum levels of Cu, Apo B and IL6 were significantly increased in blood samples of diabetic cardiac patients compared to diabetic control (P<0.0001). Mean serum levels of Zn, Apo A1 were significantly decreased in blood samples of diabetic cardiac patients compared to diabetic control (P<0.0001).

Conclusion: This study concluded that there is increased level of serum copper, Apo B, IL 6, HbA1c in diabetic cardiac complication patient as compared to diabetes patients and there is decreased level of serum zinc, Apo A1 in diabetes cardiac complication patients as compared to diabetic patients.

Keywords: Diabetes mellitus, Cardiovascular disease, ApoA1, Apo B, IL6, Zn, Cu

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