Citation Information :
Agrawal K, Solanki U. Vitamin C, Vitamin E and lipid peroxidation status in type-2 diabetic mellitus patients with or without nephropathy. 2023; 2 (1):32-35.
Background: Free radical and oxidative stress is considered to be a conjoining tie between diabetes mellitus (DM) and its complications including nephropathy.
Objectives: To assess levels of antioxidant vitamins E, vitamin C and lipid peroxidation status in Indian patients of type 2 DM with nephropathy.
Materials and Methods: This cross sectional study was conducted at tertiary care teaching hospital. All the diabetic patients with or without nephropathy during the study period were enrolled in the study. Nondiabetic healthy hospital staffs were selected as controls for the study. Serum levels of malondialdehyde (MDA), Vitamin E, Vitamin C levels were estimated in controls, patients of type 2 DM without complication and with nephropathy.
Results: Plasma levels of HbA1c, serum LDL, HDL, MDA, vitamin E and C were found significantly different in all three groups viz; controls, uncomplicated diabetic and diabetic nephropathy patients. Vitamin E and vitamin C levels showed negative correlation with plasma HbA1c levels in control and DN (diabetic nephropathy) patients. Both the vitamins negatively correlated with serum MDA levels in diabetic uncomplicated and diabetic nephropathy patients.
Conclusions: The present study concluded that free radical injury (oxidative stress) is increased and antioxidants defence (Vitamin E and C) were compromised in type 2 DM. These derangements are of a higher magnitude in patients of type 2 DM with nephropathy.
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