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Volume  2 (2023)
Volume  1 (2022)
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VOLUME 2 , ISSUE 1 ( January-December, 2023 ) > List of Articles

Original Article

Role of apolipoproteins (Apo A1 and Apo B), Interleukin-6 (IL6), Copper (Cu) and Zinc (Zn) in patients with diabetic cardiac complications

Satish Ameta, Manish Kalal, Deepti Bhatt, Himanshu Patel, Neha Sharma

Keywords : Diabetes mellitus, Cardiovascular disease, ApoA1, Apo B, IL6, Zn, Cu

Citation Information : Ameta S, Kalal M, Bhatt D, Patel H, Sharma N. Role of apolipoproteins (Apo A1 and Apo B), Interleukin-6 (IL6), Copper (Cu) and Zinc (Zn) in patients with diabetic cardiac complications. 2023; 2 (1):27-31.

DOI: 10.5005/jamu-2-1-27

License: CC BY-NC 4.0

Published Online: 01-01-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: Diabetes mellitus can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure. Diabetes is also associated with alteration in the amount of several classes of lipoprotein, apolipoproteins and minerals. Objectives: To find out the correlation of Apolipoproteins Apo A1 and Apo B, IL6, Cu and Zn trace elements in diabetic patient with cardiac complications. Materials and Methods: This study was performed on 50 patients with diabetic cardiac complications and 50 diabetic patients. Blood sample was collected by vein puncture using an aseptic technique. Serum was separated from the sample and was analyzed for biochemical parameters. Results: Mean serum levels of Cu, Apo B and IL6 were significantly increased in blood samples of diabetic cardiac patients compared to diabetic control (P<0.0001). Mean serum levels of Zn, Apo A1 were significantly decreased in blood samples of diabetic cardiac patients compared to diabetic control (P<0.0001). Conclusion: This study concluded that there is increased level of serum copper, Apo B, IL 6, HbA1c in diabetic cardiac complication patient as compared to diabetes patients and there is decreased level of serum zinc, Apo A1 in diabetes cardiac complication patients as compared to diabetic patients.

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